Aydin Aghdashloo was born in 1940 in Rasht, to a Caucasian father and a Qajar mother. He was fascinated by painting since childhood and was able to sell his first painting at the age of 14. This painting was a copy of Velazquez with a price of 40 Tomans.

At the age of 19, Aghdashloo entered the Faculty of Fine Arts of Tehran University, but left his studies halfway through. In 1975, he held his first solo exhibition at the Iran-American Association in Tehran. In 2014, after a gap of almost 40 years, Aghdashloo held his second solo exhibition at Assar Art Gallery. Also, Aydin Aghdashloo's first appearance in auctions goes back to 2007 at Christie's auction house.

After Iran's revolution, Aydin Aghdashloo was mostly engaged in writing and graphic design, and his works were published in many magazines. He has a teaching experience in Boys Visual Arts Conservatory and Tehran School of Decorative Arts. Aydin Aghdashloo was also responsible for the establishment of the Reza Abbasi Museum and was its head for some time.

From the beginning of the 70s, Aghdashloo carefully reconstructed the works of the old masters and deliberately destroyed them in his own way, and the result was the collection called "Memories of Destruction". By choosing the works of the artists of the Renaissance period, he told a personal story about them. Over time, he used Iranian art such as Safavid and Qajar era painting and calligraphy in his works. "Fire and Snow Years", "Apocalypse Disaster", "Mystery" and "Angels' Intercession" are among his other works.

Dariush Shayegan, an Iranian thinker, writes about Aydin Aghdashloo: "His art does not have harsh and sad feelings, it does not give way to the glories of the heart, it does not give in to the pulse of instinct and the enchantment of the unconscious world, and it does not surrender itself to the demons of anxiety, and to the confusion of the senses and to It does not allow temptation and greed. On the contrary, his intellect is clear and transparent and a little cold. Aghdashloo has that rare insight that enables him to look at the absurdity of this crazy world with a detached gaze.